The condensation of phosphonoacetonitriles with isothiocyanates performed in tetrahydrofurane, in the presence of potassium tert-butoxide, leads to a potassium thiolate intermediate. This last one reacts in situ with brominated derivatives to give some phosphonylated thiazolines. The identification of all the synthesized products was made by IR and NMR (1H, 13C, 31P) spectroscopies.
I. Jalloul, M.L. Efrit, A. Ben Akacha
Phosphonoacetonitrile, isothiocyanate, cyanothioacetamide phosphonyle, thiazoline, thiazolidinone