JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Synthèse de nouvelles 3-cyanopyridine-2(1H)-thiones,thiéno[2, 3-b] et Pyrazolo[3,4-b]pyridines

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Synthesis of novel 3-cyanopyridine-2(1H)-thiones, thieno[2,3-b]pyridines and pyrazolo[3,4-b]pyridines. Michael addition of ethyl 4,4,4-trifluoroacetate-3-oxobutanoate and 1,1,1-trifluoropentan-2,4-dione on arylmethylenecyanothioacetamides 1 in refluxing ethanol leads to the corresponding 3-cyano-pyridine-2(1H)-thiones 4 and 7. The synthesis of a new series of pyrazolo[3,4-b]pyridines 9 and thieno[2,3-b]pyridines 11 by alkylation and cycloaddition of the synthetized products 4 and 7 is reported. The structure of obtained products was determined on the basis of their IR and NMR data.

S. Askri, M.L. Efrit

arylidenecyanothioacetamides, pyridine-2(1H)-thiones, Thorpe-Ziegler reaction

Pages 119-125

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