In soft conditions, simple or functionalized thiols react on ammonium salts of Mannich adducts 1 to lead to the corresponding allylic thioethers 3. In the presence of primary amines these acceptors generate the highly functionalized aminothioethers 4.
H. M’Rabet, M. Ould M’Hamed, A. Ayari, M.L. Efrit
Mannich adduct, alkyl mercaptoacetate, Michael acceptor