Efficient synthesis of chiral 1,3-diols and of 1-substituted-propan-1-ols through asymmetric hydrogenation
Written by sctunisie no commentsAsymmetric hydrogenations of an achiral β-keto ester using a chiral diphosphine-ruthenium catalyst to set the hydroxyl function in a stereo controlled manner were used in key-step towards the total synthesis of both enantiomers of secondary alcohols with excellent enantioselectivity (>99% ee) and high yields.
R. Touati, B. Ben Hassine
Asymmetric hydrogenation, atmospheric pressure, β-hydroxy esters, 1,3-diols, monotosylate 1,3-diols, secondary alcohols
Pages 127-139
