Novel spiroheterocyclic succinimide-derivatives containig γ-butyrolactone moities were prepared via spirocyclization using N-bromosuccinimide (NBS), N-iodosuccinimide (NIS) or silver carbonate (Ag2CO3). Importantly, in all cases, the reaction seems to be highly regioselective because during the cyclization process only the exo-dig products were obtained in high yields. The resulting heterocycle derivatives could serve as intermediates for the access to new natural alkaloids with a biological interest.
M.M. Rammah, M. Othman, M. B. Rammah
spirolactones, halocyclization, succinimide, butyrolactone