A total synthesis of (E)-11-hydroxyundec-2-enoic acid - A new homologous royal jelly acid
Written by sctunisie no commentsA total synthesis of (E)-11-hydroxyundec-2-enoic acid 10, an homologous of royal jelly acid and queen substance of honey bee was performed using commercially available nonan-1,9-diol. The general strategy including some key steps was based on the Wittig-Horner reaction of triethyl phosphonate in water in the presence of potassium carbonate on the protected 9-hydroxynonanal.
T. Turki, S. Khamri, H. Amri
Wittig-Horner reaction, (E)-11-Hydroxyundec-2-enoïc acid, royal jelly, honey bee
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