JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Design and Synthesis of new antimicrobial [1,2,4]triazolo[1,5-c]pyrimidines

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The synthesis of 14-(aryl)-14H-naphtho[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2- acetonitriles 4a-e has been accomplished using three steps of reaction using the 2-amino-naphthopyrane-3-carbonitriles 1a-e as useful key intermediates. Compounds 4a-e are used as precursors for the preparation of new triazolopyrimidine derivatives 5, 6, 7 and 8. Structures of these compounds were established on the basis of 1H NMR, 13C NMR and HRMS. The synthesized compounds were also screened for their antimicrobial activity.

A. Ben Said, A. Rahmouni, M. Daami-Ramadi, A. Romdhane, H. Ben Jannet

Naphtopyrane, Triazolo[1,5-c]pyrimidine acetonitrile, Antibacterial activity, Antifungal activity

Pages 94-104

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