JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Enantioselective synthesis of β-hydroxyamides via asymmetric hydrogenation of β-ketoamides using chiral Ru(II)-catalysts

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Asymmetric hydrogenation of β-ketoamides 1a-i using chiral Ru(II)-catalysts with BINAP, MeO-BIPHEP, SYNPHOS and DIFLUORPHOS as atropisomeric ligands leads to the corresponding β-hydroxyamides 2a-i with good chemical yields (75% to 95%) and high enantioselectivities (73% to 99%) under 5 to 10 bar of hydrogen pressure.

T. Gmiza, R. Touati, C. Deport, V. Ratovelomanana-Vidal, J.P. Genet, B. Ben Hassine

catalysts, ruthenium, hydrogenation, enantioselectivity

Pages 157-166

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