Solvent-free Knœvenagel reaction of malonic acid
Written by sctunisie no commentsKnœvenagel reaction is applied to the condensation of malonic acid with aromatics aldehydes in solvent-free conditions under conventional heating. This solvent-free reaction leads in a single step to corresponding unsaturated diacids, when the basic entities such K2CO3, Na2CO3 KHCO3 and KOH are used. The application of the same reaction with pyridine, piperidine and quinoline, acting as catalysts, leads after decarboxylation, to the insaturated monoacid.
M. Fakhfakh, M. Abid, S. Abid, R. El Gharbi
malonic acid, Knœvenagel reaction, solvent-free synthesis
Pages 43-47
