Optimisation de la réaction d’acylation du diphényléther par l’acide coumalique. Effet de l’acide triflique
Written by sctunisie no commentsThree methods were used in the diphenylether (DPE) acylation reaction by the coumalic acid (2-pyrone-5-carboxylic) in order to obtain a new bisdiene of the bispyrone type. The first one consists in a Friedel and Crafts acylation in the presence of a Lewis acid. In the second way we used the Eaton reagent (mixture: CH3SO3,H/P2O5). Finally use of the mixture: trifluormethanesulfonic (triflic) acid/P2O5 alone or added to the methanesulfonic acid was described in the third part. The bispyrone obtained with a yield varying from 70 to 90% was analyzed by proton and 13C NMR and by HPLC/MS.
O. Mzani, H. Ben Romdhane, R. Mercier, M. Baklouti
bispyrones, acylation, Eaton reagent, trifluoromethanesulfonic acid
Pages 253-260
