JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Lateral functionalization of phosphonate quinolines

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An efficient metalation-functionalization of diethylmethylphosphonate quinolines, at low-temperature, with suitable electrophiles in the presence of n-BuLi in THF, is described herein. It constitutes a general method for the synthesis of halogenophosphonoquinolines and vinylquinolines.

N. Jelaiel, T. Saïed, M.L. Efrit

methylphosphonate, quinoline, halogenophosphonoquinoline, vinylquinoline

Pages 121-126

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