JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Ultrasonic activation of Nozaki-Hiyama-Kichi reaction in the presence of phase transfer catalysis

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The addition of compounds organochromium with aldehydes originally described by Nozaki-Hiyama-Kishi has evolved to become a very powerful method leads to the formation of C-C bonds. We present a process that allows the coupling of aldehydes with organic halides under Ultrasonic irradiation and in the presence of phase transfer catalysis in a medium consisting of anhydrous CrCl2 and an amount of Mn in combination with trimethylsilane chloride (Me)3SiCl to finally produce secondary alcohols. Yields are increased through the ultrasonic irradiation in the presence of the phase transfer catalyst at ambient temperature and for a very short duration. The isolated product has a high purity.

L. Mhamdi, K. Said, G. Rigane, R. Ben Salem, Y. Moussaoui

Nozaki-Hiyama-Kishi, organochromium, Ultrasonic irradiation, phase transfer catalysis, C-C bond formation

Pages 61-67

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