Short Note: Synthesis of Ambrox® from sclareol by two pathways in three steps
Written by sctunisie no commentsStarting from sclareol 2 , Anthrax® 5 has been constructed by two separate, three steps pathways, via sclareolide 1, or via sclareol oxide 3. In the first synthesis the key reactions are formation of sclareolide 1 from sclareol by oxidative degradation with O3/peroxides/NaOH, and its reduction to the diol 4 with LiAlH4. The second sequence involves the synthesis of sclareol oxide 3 , which is concerted by reaction with ozone and in situ reduction with NaBH4 to the diol 4. Cyclisation of diol 4 obtained by either method, then yields Ambrox 5.
A. Fekih, A. Khemiss
Ambrox, sclaréol, sclaréolide, sclaréol oxyde
Pages 73-75
