JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Functionalization of s-tetrazine: Preparation of new compounds with high synthetic potential

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Application of thiol-ene chemistry on chloro-allyloxy-tetrazine shows an incompatibility of the s-tetrazine ring with radical addition. Thus, in order to synthesize new dialkoxy-s-tetrazines including a fluorinated substituent, thiol was added across allylalcohol and the resulting intermediate was then allowed to react with dichloro-s-tetrazine. Subsequent substitution on the second chlorine leads to disubstituted derivatives.

R. Guermazi, G. Clavier, A. Hedhli, P. Audebert

Radical addition, fluorine, tetrazine, thiol

Pages 8-13

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