Synthesis of 17α-acetoxy-6,21-dimethyl3, 20-dioxo-19 norpregna-4,6-diene
Written by sctunisie no commentsA search for increasing progestin activity has led to the synthesis of the 17α-acetoxy-6,21-dimethy1-3,20-dioxo-19- norpregna-4,6-diene. This new compound has been obtained from the 19-norandrostenedione which was subjected to, a Wittig reaction with Ph3P=CHEt, followed by oxidation of Δ-17(20) to 17α-OH and 20-oxo by OsO4 and triethylamine N-oxide hydrogen peroxide, and finally elaboration in to the 6-methyl-4,6-diene-3-one according to know methodologies.
M.N. Nasraoui, A. Piasco, C. Tchernatinsky
Pages 427-434
