JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Evaluation of antioxidant activity of selected new synthesized oxazolidin-2-one derivatives

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Background: In order to envisage that the two bioactive molecules (pharmacophores) if linked together could generate novel molecular templates which are likely to exhibit interesting biological properties, gathering the two patterns in one molecule and combining their properties was our purpose and presents a new way to increase the efficiency of biologically active molecules. This field of research have gained too much interest as proven by large number of reviews and research articles published in the current years.
Objective: To the best of our knowledge, oxazolidinone derivatives are widely used as antipenetrant agents in a cosmetic and/or dermatologie composition but knowledge of their antioxidant properties is limited or even missing. Therefore, as a part of our ongoing studies toward the development of novel interesting biologically active agents, the evaluation of antioxidant activity of a series of ω-(oxathiolan-2-thion-5-yl)-α-oxazolidin-2-ones (1-3)a-b will be discussed in this study.

S. Ghrab, K. Lahbib, L. Aroua, M. Beji

Biheterocycles, 2-oxazolidinones, oxathiolane-2-thione, PEG chain, antioxidant activity

Pages 368-374

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