JOURNAL of the Tunisian Chemical Society

Synthesis of a series of cyclic fused-isoxazolines has been accomplished by regioselective and chemioselective 1,3-dipolar cycloaddition of ethyl 1-allyl-2-benzyl-3-oxo-2, 3-dihydro-1H-isoindole-1-carboxylates 5 to arylnitrile oxides 6. The structure of the cycloadducts was elucidated by ¹H and ¹³C NMR spectroscopy. The regioselectivity observed is in accordance with the one normally found in nitrile oxide cycloaddition with terminal alkenes.

A. Laouiti, M.M. Rammah, M. Askri, M.B. Rammah

Pages 83-88