JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Synthesis and characterization of fluorinated 1,3,4-oxadiazole-2-thiones

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Oxadiazoles have attracted a wide attention of chemists in search of the new therapeutic compounds. Fluorine atom is often introduced into organic molecules to improve such a therapeutic activity. In this context, a series of perfluoroalkylated 1,3,4-oxadiazole-2-thiones was prepared from the corresponding hydrazides. Characterization of these new compounds indicates a displacement of the tautomeric equilibria in favour of the thione form.

R. Ben Châabane, A. Hedhli

hydrazide, 1,3,4-oxadiazole-2-thione, fluorine.

Pages: 25-28

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