Oxadiazoles have attracted a wide attention of chemists in search of the new therapeutic compounds. Fluorine atom is often introduced into organic molecules to improve such a therapeutic activity. In this context, a series of perfluoroalkylated 1,3,4-oxadiazole-2-thiones was prepared from the corresponding hydrazides. Characterization of these new compounds indicates a displacement of the tautomeric equilibria in favour of the thione form.
R. Ben Châabane, A. Hedhli
hydrazide, 1,3,4-oxadiazole-2-thione, fluorine.