Nouvelle méthode de préparation de complexants du ferIII et synthèse ameliorée de l’intermédiaire pyrocatéchol monobenzyléther
Written by sctunisie no commentsA new synthetic route is reported for siderophores APn having pyrocatechol groups located α to each carboxylic acid of a α,ω-linear diacid. The use of a benzyl group for protecting a phenolic hydroxide allows an easy deprotection by hydrogenolysis and gives a better yield for the multistep synthesis. An improved synthetic procedure for preparing the intermediate 2-benzyloxyphenol (pyrocatechol monobenzylether), by solid-liquid phase transfer catalysis, is reported (K2CO3, Aliquat, xylene; yield = 75%).
M. Ismaïl, A. Zinelabidine, F. Mhenni, R. Gallo
siderophores, protecting group, hydrogenolysis, ether cleavage, Phase Transfer Catalysis (PTC)
Pages 1591-1598
