Synthesis of 2-substituted-1,4-dioxanes

Written by sctunisie 30 december 1995 no comments

The synthesis of 2-substituted-1,4-dioxanes may be realized by ring opening of 3-(2-chloroethoxy)-1,2-epoxypropane by nuclephiles (F^-. N₃^-, CH₃OH, PhSH) then cyclo-dehydrochloration of the formed ω-chloroalcohol for the 2-functionalized one, and from the bromoalkoxylation of olefins with N-bromosuccinimide (NBS) and ethylene glycol, followed by the cyclization of the formed bromohydrins for the 2-alkylated others.

M. Romdhani, M.M. Chaabouni, A. Baklouti

Pages 661-669

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