Synthèse et caractérisation de copolymères styréniques porteurs de groupes « pendants » bases de schiff dérivées d’amines médicaments
Written by sctunisie no commentsIn order to study the effect of polymeric structure on drug release, different SCHIFF bases have been prepared by reaction of (m,p)-vinylbenzaldehyde with the following primary amines as organic models: aniline, benzylamine, 2-phenylethylamine, 3-phenylpropylamine, benzocaine and procaine. These SCHIFF bases have been copolymerized with N-2-vinylpyrrolidone (VP) in initial molar ratio of 4/96 (SCHIFF base: VP) using AIBN (5% in weight) as initiator in THF under nitrogen atmosphere. These obtained copolymers have been characterized and the incorporation ratios have been also calculated.
H. Merine, Z. Bengharez, L. Belarbi, A. Mesli
Active agent, SCHIFF base, copolymerization, incorporation ratio, glass transition temperature Tg, molecular weight
Pages 259-266
