JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Etude préliminaire sur la synthèse des poly(ester amide)s furano-aliphatiques

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New poly(ester-amide)s based on 5,5’-isopropylidene bis(ethyl 2-furoate), ethandiol and hexan-1,6 diamine, were prepared by melt polycondensation. Two techniques were investigated in order to determine the best conditions for synthesis of furanic-aliphatic poly(ester-amide)s. These copolymers were characterized in terms of both structure and thermal properties.

R. Triki, M. Abid, S. Abid, A. Fradet

Poly(ester-amide)s, Furanic diesters, Ethandiol, Hexan-1,6 diamine

Pages 93-99

Réactivité des 3-cyano iminocoumarines vis-à-vis du phénylsemicarbazide

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A novel series of benzopyrano [2,3-c] pyrazole 2-carboxamides was prepared in good yields by the reaction of 3-cyano iminocoumarins with 4-phénylsemicarbazide. A study of the effects of various physicochemical parameters governing the reaction of a model system allowed the most favourable reaction conditions to be determined. The structures of the obtained products were characterized using FTIR, 1H NMR and 13C NMR.

L. Ben Maktouf, M. Kammoun, H. Ammar, S. Abid

Iminocoumarin, semicarbazide, benzopyranopyrazole

Pages 101-106

Synthèse et caractérisation de copolymères imines supports. Etude cinétique de la libération contrôlée d’un principe actif modèle

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In the pharmaceutical industry, the use of copolymers as drugs carriers was the tool of several research because of their numerous and interesting functional properties. The binding of drugs on macromolecular supports allows a better modulation of the pharmacokinetics of drug release. Two monomers supports were synthesized with a model active agent: the p-amino-benzoïc acid (PABA). The obtained monomers were co-polymerized with N-2-vinylpyrrolidone by radicalar route, with AIBN as initiator, and characterized by IR and the rates of incorporation were determined by microanalysis. Various dosage forms able to control the drug release were established and studied. The kinetic of drug release were carried out into various physiological media of pH (1.2, 4, 6 and 8) at 37°C. The influence of the pH and the effect of the composition of the dosage forms on the whole kinetics were showed. The processes of liberation of PABA and of absorbed liquids were controlled by the diffusion of the liquid inside and the drug’s outside of the dosage forms. The application of the Cranck model, based on Fick’s laws allowed us to calculate the various diffusivities to estimate the drug release.

Z. Bengharez, H. Sehil, H. Merine, N. Chafi

copolymer carriers, PABA, dosage forms, drug release, diffusivity

Pages 107-116

Cycloaddition des arylnitriloxydes sur des dérivés de la 2-benzylidènebenzo[b]tiophen-3(2H)-one (thioaurones)

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: 1,3 dipolar cycloaddition of arylnitriloxydes with (Z)-2-arylidenebenzo[b]thiophen-3-ones, leads to the formation of new spiroisoxazolines. A study of structure determination to spiroisoxazolines via RMN 1H and RMN 13C was realized.

A. Boughaleb, M. Akhazzane, G. Al Houari, M. Daoudi, B. Garrigues, A. Kerbal, M. El Yazidi

: 1,3 dipolar cycloaddition, (Z)-2-arylidènebenzo[b]thiophèn-3-ones, arylnitriloxyde, thioaurones, spiroisoxazoline

Pages 117-122

Global chemical composition of the Mediterranean horse mackerel Trachurus mediterraneus: Variations according to muscle type and fish sex

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This work investigates the global chemical composition of the Mediterranean horse mackerel Trachurus mediterraneus (Steindachner, 1863), a coastal catch fish of the Gulf of Gabes (Tunisia). The moisture, protein, fat and ash contents variations of the fish muscle, according to the sex and the muscle type (white and red muscles) were examined. The global chemical composition of the eviscerated fish was also determined. These variations are considerable as regards moisture and fat contents. The male of eviscerated Trachurus mediterraneus presents a slightly more elevated fat content than the female (2.20 ± 0.01 against 1.60 ± 0.01 %). Calcium and sodium contents are high (234.51 ± 19.01 and 135.36 ? 26.29 mg / 100 g respectively) whereas those of iron and magnesium are low (1.43 ± 0.19 and 28.74 ? 5.25 mg / 100 g respectively). Unlike the red muscles which are rich in fat (9.86 ± 0.01 %), the white muscles are rich in moisture and protein (73.93 ± 0.70 % and 24.78 ± 0.14 % respectively).

I. Ketata Khitouni, N. Boudhrioua Mihoubi, A. Abdelmouleh, A. Bouain

Trachurus mediterraneus, global chemical composition, mineral elements, sex, muscle

Pages 123-132

Chemical composition and antioxydant properties of Washingtonia filifera leaves and flowers

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The chemical composition and antioxidant effects of extracts from Washingtonia filifera leaves and flowers were studied. Antioxidant testing assay has been done on the basis of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Among all tested extracts and the volatile fractions, butanol and ethanol ones from Washingtonia filifera leaves and flowers, were the most potent ones, the observed results indicate that they may be considered as a natural source of antioxidants having health protective potential. Chemical investigation of these extracts, led to the isolation and the identification of Tricine acetylated derivative 1a and of synthetic heterocyclic bioactive Quinazoline-2, 4-(1H, 3H) dione 2 mentioned for the first time in Washingtonia filifera (W.H). Structures were assigned on the basis of spectroscopic data, especially (1H and 13C) 1 and 2D NMR and ES Mass spectrometry.

S. Hammami, S. Ben Salem, H. Jarraya, P. Devi, A. Nefzi, Z. Mighri

Washingtonia filifera (W.H), antioxidant effects, Tricine triacetates, Quinazoline-2, 4-(1H, 3H) dione

Pages 133-137

GC, GC-MS and NMR spectroscopy Integrated Analysis of the Tunisian Pulicaria laciniata essential oil

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The essential oils from aerial parts and roots of Pulicaria laciniata were obtained by hydro distillation and analyzed by GC and GC-MS. The chemical composition of the root oil of this species is reported here for the first time. Thirty-eight components, accounting for 98.25% and 98.79% of the aerial part and root oils, respectively, were identified. The two oils were characterized by high proportion of oxygenated monoterpenes (68.46 and 85.91%) and belonged to the geranyl isobutyrate (55.91 and 77.92%) chemotype. The phenolic derivatives represented the second major fraction (17.22 and 4.85%) among which cis-isoelemicin (11.04 and 4.85%) was the predominant compound. The major constituent was isolated and identified as (Z)-geranyl isobutyrate 1, by analysis of spectroscopic data (1H-NMR, 13C-NMR, DEPT 135, CHcorr, HMBC, 1H1H COSY and NOESY experiments).

H. Ghouila, F. Hichri, L. Ghribi, S. Barrek, H. Ben Jannet

Essential oil, Pulicaria laciniata, Asteraceae, (Z)-geranyl isobutyrate, 1 and 2D-NMR

Pages: 139-144

Influence du pH d’extraction sur les propriétés gélifiantes des polysaccharides issus d'Opuntia ficus-indica

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This paper reports the influence of extraction pH on chain stiffness and gelation properties of polysaccharides from different parts of Opuntia ficus-indica. The different extract presented random coil structure, with the more extended configuration in the case of the acid extract of the nopal peels and basic extract of the fruit peels. Chain stiffness was evaluated for the extracted polysaccharides and compared using calculation from the Kratky-Porod model with two adjustable parameters (persistence length (Lp) and the molar mass per unit contour length (ML)). These parameters confirm that chain expansion of polysaccharides extracted from nopal peels in acid medium and pear peels in basic medium is related to their rigid structures. Moreover, the viscosimetric study shows that these two polymers form calcium-induced gels and are expected to be useful as thickening or gelation agent in various fields such as food and cosmetic industry.

H. Majdoub, S. Roudesli, A. Deratani

Opuntia ficus-indica, polysaccharide, selective extraction, persistence length, Ca2+-gel

Pages: 145-155

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