JOURNAL of the Tunisian Chemical Society

serving the Research, the Education and the Industry

Préparation du sclaréolide par ozonolyse du sclaréol. Synthèse de l’Ambrox® en trois étapes

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Sclareolide was obtained in high yield (> 96%) in a one pot reaction from sclareol by ozonolysis and treatment in situ by H2O2/NaOH/CH3CO3H. This commercially interesting product gave Ambrox® in very good yield (Total yield from sclareol > 85%) by reduction and subsequent cyclisation of the intermediary bicyclohomofarnesane 8α-12diol.

A. Fekih, F. Habbachi

Ambrox®, sclareol, sclareolide, ozonolysis

Pages 909-914

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