Direct substitution of vinylic bromine by an amino group: Synthesis of dimethyl -α-(aminomethylene) glutaric acid esters
Written by sctunisie no commentsNucleophilic subtitution of bromine by amines on (E)-α-(bromomethylene)glutaric acid ester leads to the corresponding enamines in high yields. Stereochemistry of the corresponding products is determined.
T. Ben Ayed, H. Amri, M.M. El Gaïed J. Villiéras
Pages 219-222
